Blocking Interleukin-12 and Interleukin-23 in the Treatment of Axial Spondyloarthritis
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Interleukin-12 and interleukin-23 inhibition in psoriatic arthritis.
The cytokines interleukin (IL)-12 and interleukin (IL)-23 have been implicated variously in the pathogenesis of psoriasis and psoriatic arthritis (PsA). By corollary, the IL-12/23 inhibitor, Ustekinumab has been developed as an approved therapeutic for the skin and musculoskeletal syndrome of psoriasis / PsA. This review describes briefly the role of IL-12 and IL-23 in the pathophysiology of ps...
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INTRODUCTION Morphea is a disease included in the group of scleroderma type autoimmune diseases. Interleukin (IL)-17A may play a role at every stage of its pathogenesis. The study aimed at evaluation of IL-17A and IL-23 (as the main cytokine which is supposed to stimulate and maintain synthesis of IL-17) in pathogenesis of morphea. MATERIAL AND METHODS The studies were performed on 41 blood s...
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ژورنال
عنوان ژورنال: Current Treatment Options in Rheumatology
سال: 2015
ISSN: 2198-6002
DOI: 10.1007/s40674-015-0021-8